Distinct Differences between TNF Receptor 1- and TNF Receptor 2- mediated Activation of NFκB
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منابع مشابه
Distinct Contributions of TNF Receptor 1 and 2 to TNF-Induced Glomerular Inflammation in Mice
TNF is an important mediator of glomerulonephritis. The two TNF-receptors TNFR1 and TNFR2 contribute differently to glomerular inflammation in vivo, but specific mechanisms of TNFR-mediated inflammatory responses in glomeruli are unknown. We investigated their expression and function in murine kidneys, isolated glomeruli ex vivo, and glomerular cells in vitro. In normal kidney TNFR1 and TNFR2 w...
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of TNFR1 leads to the recruitment of the death domain (DD)-containing adaptor molecule TNFR1-associated death domain protein (TRADD), which serves as a platDaniel F. Legler,1,2,* Olivier Micheau,1 Marie-Agnès Doucey,1 Jürg Tschopp,1 and Claude Bron1 form to recruit additional mediators (Hsu et al., 1995, Institute of Biochemistry 1996). TRADD, in turn, binds the DD-containing Ser/ University of...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2005
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2005.38.3.281